VBM
MR Imaging and Genotype/Phenotype Associations in a South African Dyslexia Cohort

Grant Start Date: 2007-07-01
Grant End Date: 2009-06-30

Principal Investigator:
Jonathan H. Burdette, M.D.

Investigators and Personnel:
Susan Shear
Funded By:
NINDS

Grant Numbers:
1R21NS056272


There is growing evidence that dyslexic readers may have neuroanatomic gray matter volume differences from control readers. However, the relationship between genotype/phenotype and gray matter volume remains unknown. This study aims to fill this knowledge gap by collecting neuroanatomical data on previously genotyped and phenotyped Afrikaners using magnetic resonance imaging. A voxel-based morphometric (VBM) analysis will identify gray matter volume (GMV) differences between the genotypic and phenotypic subgroups. This study will allow a greater understanding of which brain regions are involved in specific subtypes of this prevalent disorder and could have a great impact on remediation strategies, with tailoring of remediation to certain genotype and phenotype subgroups.