ASL Pig Study

Investigators and Personnel:
Megan Johnston
Youngkyoo Jung, Ph.D.
ASL Pig Study

Swine brain perfusion is a good model for that of humans due to the similar proportions of gray and white matter. In order to measure swine perfusion, PCASL was implemented using this model. Our investigation identified many parameters of the swine PCASL procedure that required optimization, as follows:The arterial blood velocity was measured to optimize tagging efficiency by adjusting acquisition parameters. Multiple post-labeling delays were collected so that the CBF quantification would be less sensitive to varying transit delays across the brain. Model-specific blood T1 and the M0 ratio of blood to white matter were measured for the quantification of CBF.

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